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Many COVID-19 trendlines are headed in a positive direction in the U.S., but there are lots of unknowns about what will happen this winter as vaccinations still lag behind many other countries.

On Tuesday, voters in New York City cast ballots in the Democratic primary for mayor. And it was the first time that the city used a ranked-choice voting system.

NPR's newest show, Invisibilia debuted last week and our listeners responded with a range of feedback, including one story of a harrowing commute home that may or may not be true.

The campus reported nearly 500 new cases of COVID-19 among the student body. The new omicron variant was detected "in a significant number" of positive tests, the university said.

The unusually high and low tides will be affecting coastal communities over the weekend. Scientists are calling on residents and visitors to help document the phenomenon.

The Farm Bureau's Thanksgiving report says the average cost of dinner for 10 people is $53.31. But don't cancel your meal yet: the cost for a turkey has already dropped since the survey was taken.

The explosion took place after a bus struck the tanker near the country's capital city. Dozens were injured after large crowds gathered to collect leaking fuel, officials and witnesses said.

The Federal Trade Commission says sales in 2020 were up slightly, and analysts say the increase was due to the coronavirus pandemic. But the gain looks unlikely to represent a long-term trend.

Moderna says the FDA is looking into reports of a rare side effect — myocarditis, or the inflammation of the heart muscle — in those who've gotten the shot.

Labor costs rose at their fastest pace in more than two decades last year. That growth eased a bit in the final months of 2021, which could give the Federal Reserve's inflation watchdogs some relief.